Wales have lost 10 out of their last 11 Six Nations games including three in this year’s tournament.
They are battling to avoid their first Six Nations wooden spoon in 21 years with a home match to finish the tournament against Italy on Saturday, 16 March.
“There are a few changes to the team this week as there are some players that deserve an opportunity,” said Gatland.
“It’ll be a tough, physical challenge from France on Sunday particularly up front.
“We know they will start hard and it’s about us staying in the fight, having good line speed defensively and keeping our discipline. We’re looking for an 80 minute performance.
“We’re excited to be back at home for our last two matches in front of a passionate Welsh crowd.”
Wales: Winnett; Adams, Roberts, Watkin, Dyer; Costelow, Tomos Williams; Thomas, Elias, Assiratti, Rowlands, Beard, D Jenkins (capt), Reffell, Wainwright.
Replacements: Dee, Domachowski, Lewis, Martin, Mann, Davies, Lloyd, Grady.